General Information

  • ID:  hor005993
  • Uniprot ID:  P69208
  • Protein name:  Morphogenetic neuropeptide
  • Gene name:  NA
  • Organism:  Homo sapiens (Human)
  • Family:  NA
  • Source:  Human
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Homo (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria , Eutheria , Theria , Mammalia (class), Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0005515 protein binding; GO:0008083 growth factor activity; GO:0048018 receptor ligand activity
  • GO BP:  GO:0002031 G protein-coupled receptor internalization; GO:0007049 cell cycle; GO:0007218 neuropeptide signaling pathway; GO:0031623 receptor internalization; GO:0034394 protein localization to cell surface; GO:0051044 positive regulation of membrane protein ectodomain proteolysis; GO:0051301 cell division; GO:0090068 positive regulation of cell cycle process; GO:2000179 positive regulation of neural precursor cell proliferation
  • GO CC:  GO:0005737 cytoplasm

Sequence Information

  • Sequence:  QPPGGSKVILF
  • Length:  11(1-11)
  • Propeptide:  QPPGGSKVILF
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates the proliferation of neural cells.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005993_AF2.pdbhor005993_ESM.pdb

Physical Information

Mass: 132091 Formula: C54H87N13O14
Absent amino acids: ACDEHMNRTWY Common amino acids: GP
pI: 9.7 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 4
Hydrophobicity: 28.18 Boman Index: 425
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 97.27
Instability Index: 6511.82 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  7290191
  • Title:  Conserved amino acid sequence of a neuropeptide, the head activator, from coelenterates to humans.
  • PubMed ID:  7297679
  • Title:  Synthesis of a new neuropeptide, the head activator from hydra.
  • PubMed ID:  11082041
  • Title:  Ectodomain shedding, translocation and synthesis of SorLA are stimulated by its ligand hea
  • PubMed ID:  11294867
  • Title:  
  • PubMed ID:  12530537
  • Title: